exRNAdisease

Entry Detail

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General Information

Database ID: exR0359215 RNA Name: ABCB6 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 219209772 End Site(bp): 219218994 External Links: ENSG00000115657

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CLCN5 chrX 49922596 50099235 + CHMP1A chr16 89644435 89657721 - COA1 chr7 43608456 43729717 - PA2G4 chr12 56104537 56113910 + PYCR2 chr1 225919877 225924340 - HLA-E chr6 30489509 30494194 + SNRPD2 chr19 45687454 45692569 - GADD45GIP1 chr19 12953119 12957223 - VCL chr10 73995193 74121363 + SNRPD3 chr22 24555958 24582052 + FARSA chr19 12922479 12934037 - SMDT1 chr22 42079691 42084284 + EEF2 chr19 3976056 3985463 - POU3F3 chr2 104853287 104858574 + GRK2 chr11 67266473 67286556 + GAPDH chr12 6534512 6538374 + WSB1 chr17 27294076 27315926 + MYCBP2 chr13 77044657 77327094 - SAC3D1 chr11 65040901 65044828 + PPP4C chr16 30075978 30085376 + KRT7 chr12 52232520 52252186 + AC068946.2 chr2 219209772 219222738 - PTPRS chr19 5158495 5340803 - SETD1B chr12 121804180 121832584 + ARID1B chr6 156776020 157210779 + CAMK2G chr10 73812501 73874591 - POU6F1 chr12 51186936 51217708 - PFN1 chr17 4945652 4949061 - LAMP1 chr13 113297239 113323672 + RAD51D chr17 35092208 35121522 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.