exRNAdisease

Entry Detail

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General Information

Database ID: exR0359216 RNA Name: ABCB8 RNA Type: mRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 151028422 End Site(bp): 151047782 External Links: ENSG00000197150

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand USP20 chr9 129834698 129881838 + RANBP1 chr22 20115938 20127355 + BAG6 chr6 31639028 31652705 - FKRP chr19 46746046 46776988 + SOX2 chr3 181711925 181714436 + KPNA4 chr3 160495007 160565571 - ATP6AP1 chrX 154428645 154436516 + THRA chr17 40058290 40093867 + PTK7 chr6 43076307 43161719 + FAM107B chr10 14518557 14774897 - TRMT2A chr22 20111875 20117392 - AC068946.2 chr2 219209772 219222738 - YIF1B chr19 38303558 38317273 - FLOT1 chr6 30727709 30742732 - HSPA1B chr6 31827738 31830254 + DVL3 chr3 184155377 184173614 + EME2 chr16 1772810 1781708 + OAZ1 chr19 2269509 2273490 + SLC37A4 chr11 119024114 119030906 - DDB1 chr11 61299451 61342596 - LAMB2 chr3 49121114 49133118 - SLC19A1 chr21 45493572 45573365 - NKRF chrX 119588337 119606443 - LOXL1 chr15 73925989 73952137 + TMBIM1 chr2 218274197 218292586 - APBB1 chr11 6395124 6419414 - ADNP2 chr18 80109262 80147523 + AFF4 chr5 132875395 132963634 - SENP3-EIF4A1 chr17 7563287 7578715 + SMG1 chr16 18804853 18926454 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.