exRNAdisease

Entry Detail

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General Information

Database ID: exR0359219 RNA Name: ABCC10 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 43427366 End Site(bp): 43450427 External Links: ENSG00000124574

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand GTPBP1 chr22 38705742 38738299 + PUM1 chr1 30931506 31065991 - ELMSAN1 chr14 73715122 73790285 - ZNF462 chr9 106863166 107013634 + RPL13 chr16 89560657 89566828 + DIP2A chr21 46458891 46570015 + YWHAG chr7 76326799 76358991 - DNMT1 chr19 10133345 10231286 - ERCC2 chr19 45349837 45370918 - EGFL7 chr9 136658856 136672678 + MAP3K11 chr11 65597756 65615382 - RPL18A chr19 17859910 17864153 + CLEC2D chr12 9664969 9699553 + SPATA20 chr17 50543058 50555852 + SLC12A9 chr7 100826820 100867010 + DYRK2 chr12 67648338 67665406 + SF3A2 chr19 2236824 2248655 + NCOA6 chr20 34689097 34825651 - PLCG1 chr20 41136960 41196801 + FBN2 chr5 128257909 128659185 - MCCC2 chr5 71587288 71658706 + AP5B1 chr11 65773898 65780976 - UBAC1 chr9 135932969 135961373 - MMADHC chr2 149569637 149587778 - PKMYT1 chr16 2968024 2980479 - UGP2 chr2 63840940 63891562 + FAM3A chrX 154506159 154516242 - NOTCH2 chr1 119911553 120100779 - IMP3 chr15 75639085 75648706 - PHGDH chr1 119648411 119744226 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-6780b-3p chr6 43434600 43434620 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC092139.1 chr16 81385463 81387560 + AP001266.1 chr11 65795946 65797219 - LINC01248 chr2 5602505 5691488 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.