exRNAdisease

Entry Detail

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General Information

Database ID: exR0359224 RNA Name: ABCC4 RNA Type: mRNA Chromosome: chr13 Starnd: - Coordinate: Start Site(bp): 95019835 End Site(bp): 95301475 External Links: ENSG00000125257

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KIF7 chr15 89608789 89655467 - ERFE chr2 238158970 238168900 + POLR3D chr8 22245133 22254601 + SLC5A6 chr2 27199587 27212958 - PIGC chr1 172370189 172444086 - AC007192.1 chr19 18153158 18178117 + NDUFA10 chr2 239892450 240025345 - ZBTB21 chr21 41986831 42010387 - RUVBL1 chr3 128064778 128153914 - ZDHHC20 chr13 21372573 21459370 - IFI6 chr1 27666064 27672198 - MYO1G chr7 44962662 44979088 - DPPA4 chr3 109326141 109337572 - CCT8 chr21 29055805 29073797 - BASP1 chr5 17065598 17276843 + FNBP1 chr9 129887187 130043194 - LTBP4 chr19 40592883 40629818 + LARP1 chr5 154712843 154817605 + RPL4 chr15 66498015 66524532 - RRM1 chr11 4094707 4138932 + SPOUT1 chr9 128819651 128829794 - LLGL2 chr17 75525080 75575208 + SACS chr13 23328826 23433740 - RPL27A chr11 8682788 8714759 + YIPF5 chr5 144158162 144170714 - SRP14 chr15 40035690 40039181 - FKBP8 chr19 18531751 18544077 - KMT2B chr19 35717973 35738878 + DDX41 chr5 177511577 177516961 - ING3 chr7 120950763 120977216 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand CRTC3-AS1 chr15 90620007 90717141 - DLEU1 chr13 50082169 50906856 + MALAT1 chr11 65497688 65506516 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.