exRNAdisease

Entry Detail

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General Information

Database ID: exR0359231 RNA Name: ABCD4 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74285269 End Site(bp): 74303055 External Links: ENSG00000119688

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand QSER1 chr11 32892820 32993316 + MRPL46 chr15 88459477 88467390 - MXRA8 chr1 1352689 1361777 - NSUN2 chr5 6599239 6633291 - M6PR chr12 8940361 8949761 - SIK1 chr21 43414483 43427131 - RPL10 chrX 154389955 154409168 + SFI1 chr22 31488688 31618588 + C5orf24 chr5 134845680 134859735 + RDH13 chr19 55039108 55071291 - CRYL1 chr13 20403666 20525873 - LONRF3 chrX 118974614 119018355 + ORC3 chr6 87590067 87667453 + ACOT8 chr20 45841721 45857405 - TP53RK chr20 46684365 46689444 - ZNF668 chr16 31060843 31074240 - PFN1 chr17 4945652 4949061 - LTK chr15 41503637 41513887 - TOMM40L chr1 161225939 161230746 + FBXW4 chr10 101610664 101695295 - NEO1 chr15 73051710 73305205 + SELENOS chr15 101270817 101277500 - NHP2 chr5 178149460 178153967 - EIF4H chr7 74174245 74197101 + HSP90AB1 chr6 44246166 44253888 + BTBD2 chr19 1985438 2034881 - TRIP13 chr5 892884 919357 + HSPA4 chr5 133052013 133106449 + CCDC167 chr6 37482938 37499893 - VMP1 chr17 59707192 59842255 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005519.1 chr14 74289127 74294425 - AC005562.1 chr17 30576464 30672789 + AC007952.4 chr17 19112000 19112636 - AC011476.2 chr19 55027593 55053928 - MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.