exRNAdisease

Entry Detail

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General Information

Database ID: exR0359232 RNA Name: ABCE1 RNA Type: mRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 145098288 End Site(bp): 145129524 External Links: ENSG00000164163

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MGST1 chr12 16347142 16609259 + MTX2 chr2 176269395 176338025 + RPL37A chr2 216498825 216579180 + FAM162A chr3 122384176 122412334 + ENOPH1 chr4 82430590 82461177 + ANKRD17 chr4 73073376 73258798 - SLC25A29 chr14 100291116 100306547 - INSIG1 chr7 155297776 155310235 + LAMTOR1 chr11 72085895 72103297 - GNB5 chr15 52115105 52191369 - IVNS1ABP chr1 185296388 185317273 - TIMMDC1 chr3 119498547 119525090 + HOXA3 chr7 27106184 27152581 - STMN1 chr1 25884181 25906991 - UGP2 chr2 63840940 63891562 + RPL3 chr22 39312882 39320389 - PGK1 chrX 77910739 78129295 + RBL2 chr16 53433977 53491648 + BCAT1 chr12 24810024 24949101 - RPS23 chr5 82273320 82278396 - TNPO2 chr19 12699194 12724011 - TUBB chr6 30720352 30725426 + CHTF8 chr16 69118010 69132578 - CLPTM1L chr5 1317752 1345099 - RAB10 chr2 26034084 26137454 + MDH2 chr7 76048051 76067508 + CREBZF chr11 85659708 85682908 - C19orf48 chr19 50797704 50804929 - EWSR1 chr22 29268009 29300525 + ATP5MG chr11 118401606 118431496 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL157871.6 chr14 100279959 100291456 - FAM215B chr17 46558830 46562795 - MAPKAPK5-AS1 chr12 111839764 111842902 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.