exRNAdisease

Entry Detail

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General Information

Database ID: exR0359233 RNA Name: ABCF1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 30571393 End Site(bp): 30597179 External Links: ENSG00000204574

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HLA-DRB1 chr6 32578769 32589848 - ZNF501 chr3 44729596 44737083 + TMEM250 chr9 136114581 136118875 - MT-CO1 chrMT 5904 7445 + GLUL chr1 182381704 182392206 - CIC chr19 42268537 42295797 + MTRNR2L8 chr11 10507894 10509186 - MYLIP chr6 16129086 16148248 + IFIT3 chr10 89327997 89340971 + ZNF581 chr19 55635459 55645623 + MAU2 chr19 19320829 19358754 + CERS2 chr1 150960583 150975004 - TNRC6A chr16 24610209 24827632 + PDP2 chr16 66878589 66895754 + BSG chr19 571277 583493 + EEF1G chr11 62559596 62574086 - PTBP1 chr19 797075 812327 + AP1S2 chrX 15825806 15854931 - FTL chr19 48965309 48966879 + IQGAP1 chr15 90388242 90502239 + SURF4 chr9 133361450 133376166 - SELENON chr1 25800176 25818221 + RPS6 chr9 19375715 19380236 - PDCD6IP chr3 33798571 33869707 + GPC6 chr13 93226807 94408020 + VPS26A chr10 69123512 69174412 + CYFIP2 chr5 157266079 157395595 + MFSD5 chr12 53251251 53254405 + AC005832.4 chr12 4604944 4662643 + BZW2 chr7 16646131 16706523 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-302c-3p chr4 112648366 112648388 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC000068.1 chr22 19447893 19450105 + AC010642.2 chr19 58309727 58327248 - DANCR chr4 52712404 52720351 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.