exRNAdisease

Entry Detail

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General Information

Database ID: exR0359234 RNA Name: ABCF2 RNA Type: mRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 151207837 End Site(bp): 151227166 External Links: ENSG00000285292

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand COX7C chr5 86617928 86620962 + ABCF2 chr7 151207837 151227166 - EIF3L chr22 37848868 37889407 + PROM1 chr4 15963076 16084378 - MTG1 chr10 133394094 133422520 + SPG11 chr15 44562696 44663678 - SUV39H2 chr10 14878820 14904315 + MAP4 chr3 47850690 48089272 - BTBD2 chr19 1985438 2034881 - TRAPPC12 chr2 3379675 3485094 + DYNLL2 chr17 58083419 58095542 + IL32 chr16 3065297 3082192 + STAT5B chr17 42199177 42276707 - RPS4X chrX 72255679 72277248 - MCOLN1 chr19 7522624 7534009 + OST4 chr2 27070472 27071654 - SERPINE1 chr7 101127104 101139247 + CCT4 chr2 61868085 61888671 - ENO1 chr1 8861000 8879190 - ELOVL5 chr6 53267398 53349179 - CD164 chr6 109366514 109382467 - SLC37A4 chr11 119024114 119030906 - AL360181.3 chr10 133380017 133420271 + PHIP chr6 78934419 79078254 - LPGAT1 chr1 211743457 211830763 - BCAT2 chr19 48795062 48811029 - UBB chr17 16380798 16382745 + ERMP1 chr9 5765076 5833117 - UBE2Q1 chr1 154548577 154559028 - SNRNP40 chr1 31259568 31296788 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-107 chr10 89592756 89592778 - hsa-miR-625-5p chr14 65471116 65471136 + hsa-miR-423-5p chr17 30117095 30117117 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005487.1 chr7 108598352 108639349 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.