exRNAdisease

Entry Detail

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General Information

Database ID: exR0359235 RNA Name: ABCF3 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 184186023 End Site(bp): 184194012 External Links: ENSG00000161204

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand STARD10 chr11 72754729 72793681 - TRIOBP chr22 37697048 37776556 + ABCF2 chr7 151207837 151227166 - AFDN chr6 167826922 167972023 + MBD5 chr2 148021011 148516971 + RARB chr3 25174332 25597932 + EPN3 chr17 50532682 50543750 + TPI1 chr12 6867119 6870948 + PPP1R16B chr20 38805697 38923024 + MATR3 chr5 139273752 139331671 + RAB43 chr3 129087569 129122801 - EXOC7 chr17 76081016 76121576 - SSR4 chrX 153793516 153798499 + RPS19 chr19 41860255 41872925 + ZEB2 chr2 144364364 144521057 - HOXD3 chr2 176136612 176173102 + KRR1 chr12 75490863 75511636 - LIG3 chr17 34980512 35009743 + Z83844.1 chr22 37686414 37726503 + RPL13 chr16 89560657 89566828 + SNRPG chr2 70281362 70293740 - EEF1A1 chr6 73515750 73523797 - PDCD7 chr15 65117379 65133808 - MAPKAP1 chr9 125437393 125707234 - RPS6 chr9 19375715 19380236 - GGA3 chr17 75236599 75262363 - RERE chr1 8352397 8848921 - SAT1 chrX 23783173 23786226 + MTRNR2L12 chr3 96617188 96618236 - MARCKSL1 chr1 32333839 32336233 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-15a-5p chr13 50049167 50049188 - hsa-miR-15b-5p chr3 160404607 160404628 + hsa-miR-34c-5p chr11 111513451 111513473 + hsa-miR-497-5p chr17 7017979 7017999 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016949.1 chr3 196912646 196914579 + AL355075.4 chr14 20343048 20343685 - LINC00858 chr10 84267747 84294659 + RMRP chr9 35657751 35658018 - SRRM2-AS1 chr16 2737076 2752600 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.