exRNAdisease

Entry Detail

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General Information

Database ID: exR0359239 RNA Name: ABHD10 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 111979010 End Site(bp): 111993368 External Links: ENSG00000144827

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPN2 chr20 37178410 37241619 + STAC2 chr17 39210541 39225945 - GLUL chr1 182381704 182392206 - COL4A2 chr13 110305812 110513209 + YBX3 chr12 10699089 10723323 - CXCR4 chr2 136114349 136118149 - LBHD1 chr11 62662817 62672255 - PPIA chr7 44796680 44824564 + C11orf98 chr11 62662816 62665217 - RPL13 chr16 89560657 89566828 + MBD4 chr3 129430944 129440179 - MTRNR2L8 chr11 10507894 10509186 - DIDO1 chr20 62877738 62937952 - MYO1G chr7 44962662 44979088 - CTSZ chr20 58995185 59007254 - EEF1D chr8 143579697 143599541 - AP001458.2 chr11 62649694 62665178 - TBP chr6 170554302 170572870 + RPL3 chr22 39312882 39320389 - INTS12 chr4 105682627 105895986 - RPS23 chr5 82273320 82278396 - ATXN7 chr3 63864557 64003462 + MPP6 chr7 24573268 24694193 + RPS5 chr19 58386400 58394806 + RPL27A chr11 8682788 8714759 + TBC1D10B chr16 30357102 30370494 - TALDO1 chr11 747415 765012 + CLCN3 chr4 169612633 169723673 + ZNF277 chr7 112206695 112343934 + UBXN7 chr3 196347662 196432430 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.