exRNAdisease

Entry Detail

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General Information

Database ID: exR0359244 RNA Name: ABHD14B RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 51968510 End Site(bp): 51983409 External Links: ENSG00000114779

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand FTL chr19 48965309 48966879 + SMARCD1 chr12 50085200 50100707 + UTP3 chr4 70688532 70690551 + RPL13A chr19 49487554 49492308 + NELFB chr9 137255327 137273542 + HLA-DPB1 chr6 33075990 33089696 + RIC8A chr11 207511 215113 + GATD1 chr11 767220 777488 - AC010422.3 chr19 12643831 12648397 - RTCA chr1 100266207 100292769 + CCDC86 chr11 60842113 60851081 + ZNF160 chr19 53066606 53103436 - RHOA chr3 49359145 49412998 - RPL37 chr5 40825262 40835222 - EEF2 chr19 3976056 3985463 - RPS6 chr9 19375715 19380236 - JOSD2 chr19 50505998 50511353 - SSRP1 chr11 57325986 57335892 - PABPC1 chr8 100685816 100722809 - PCBP4 chr3 51957454 51974016 - RABGEF1 chr7 66682164 66811464 + GIMAP1-GIMAP5 chr7 150716668 150743646 + NDUFA2 chr5 140638740 140647785 - AGTPBP1 chr9 85546539 85742029 - TRA2B chr3 185914558 185938103 - UGT8 chr4 114598770 114678225 + VCL chr10 73995193 74121363 + SLC25A39 chr17 44319625 44324870 - AC027644.4 chr7 66628958 66811189 + DLX1 chr2 172084740 172089677 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1286 chr22 20249145 20249165 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC115284.1 chr3 51961212 51974031 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.