exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359246 RNA Name: ABHD16A RNA Type: mRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 31686955 End Site(bp): 31703356 External Links: ENSG00000204427

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CBSL chr21 6444869 6468040 - FBXO45 chr3 196568611 196589059 + SENP6 chr6 75601509 75718281 + ZNF711 chrX 85244032 85273362 + WLS chr1 68098473 68233120 - RPA1 chr17 1829702 1900082 + ARID1B chr6 156776020 157210779 + GCN1 chr12 120127202 120194715 - FASTKD5 chr20 3146519 3159865 - VIPR1 chr3 42489299 42537573 + MRPL54 chr19 3762682 3768575 + RPL18 chr19 48615328 48619184 - CHD1 chr5 98853985 98928957 - TRAF4 chr17 28744005 28750956 + PTMS chr12 6765516 6770952 + FLNC chr7 128830377 128859274 + RAB1B chr11 66268590 66277492 + UCHL1 chr4 41256413 41268455 + CBS chr21 43053191 43076943 - NOL6 chr9 33461353 33473930 - TMEM50A chr1 25338317 25362361 + SLC39A1 chr1 153959099 153968184 - MAF chr16 79585843 79600737 - PACSIN2 chr22 42835412 43015149 - MOB2 chr11 1469457 1501247 - GJA1 chr6 121435595 121449727 + LIG3 chr17 34980512 35009743 + RPS27L chr15 63125872 63158021 - SLC25A28 chr10 99610522 99620609 - CCT7 chr2 73233420 73253021 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.