Entry Detail



General Information

Database ID:exR0359248
RNA Name:ABHD17A
RNA Type:mRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):1876810End Site(bp):1885547
External Links:ENSG00000129968



Disease Information

Disease Name:Amyotrophic Lateral Sclerosis
Disease Category:Nervous System Diseases
MeSH ID:D000690
Type:Diseases Category/Nervous System Diseases
Alias:Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis



Expression Detail

GEO ID:GSE121519
Description:Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.
Experimental Design:Disease vs Control
Case Disease Type:Amyotrophic Lateral Sclerosis
Case Disease SubType:NA
Case Sample:Amyotrophic Lateral Sclerosis
Control Sample:Healthy
Number of Case:4
Number of Control:4
Number of Samples:8





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SLC20A2
chr8
42416475
42541926
-
PPP4R3A
chr14
91457611
91510554
-
AP001931.1
chr11
57741779
57804771
+
EFNB2
chr13
106489745
106535662
-
DNAJB1
chr19
14514769
14529770
-
RPS15
chr19
1438358
1440494
+
MSH5-SAPCD1
chr6
31740020
31764851
+
TUBB2A
chr6
3153666
3157544
-
NBEAL2
chr3
46979666
47009704
+
PRPF6
chr20
63981132
64033100
+
PIP5K1C
chr19
3630183
3700479
-
CEBPG
chr19
33373685
33382686
+
NAA16
chr13
41311267
41377030
+
SUPT5H
chr19
39436156
39476670
+
MT-CO2
chrMT
7586
8269
+
LUC7L2
chr7
139340359
139423457
+
AC091167.2
chr15
90249556
90272208
+
ELMO2
chr20
46366050
46432985
-
HNRNPH1
chr5
179614178
179634784
-
ACOT7
chr1
6264269
6394391
-
SETD5
chr3
9397615
9479240
+
ABHD17C
chr15
80679684
80755621
+
GPX4
chr19
1103926
1106791
+
EIF5
chr14
103333544
103345025
+
NUB1
chr7
151341699
151378449
+
FGFR1
chr8
38400215
38468834
-
NF2
chr22
29603556
29698598
+
RBCK1
chr20
407498
430966
+
UPF1
chr19
18831938
18868236
+
SLC25A3
chr12
98593591
98606379
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:GSE121519
Sample Source:Cerebrospinal Fluid
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:2
Num of detected RNAs of this Type:17787
Sample treatment protocol:Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant.
RNA Extract protocol:Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted.
RNA library preparation protocol:Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.



Reference

PMID:30630471
Title:Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid
Author:Otake K, Kamiguchi H, Hirozane Y
Journal:BMC Med Genomics. 2019 Jan 10;12(1):7.
Description:The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.