exRNAdisease

Entry Detail

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General Information

Database ID: exR0359249 RNA Name: ABHD17B RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 71862452 End Site(bp): 71910931 External Links: ENSG00000107362

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand FBN2 chr5 128257909 128659185 - EIF4G2 chr11 10797050 10808940 - TXNDC12 chr1 52020131 52055191 - CSTF3 chr11 33077188 33162371 - GDI2 chr10 5765223 5842132 - VAT1 chr17 43014607 43025123 - PNRC2 chr1 23956839 23963462 + MDK chr11 46380756 46383837 + IBTK chr6 82169986 82247754 - TMPO chr12 98515512 98550379 + SRP9 chr1 225777813 225790468 + FBXL20 chr17 39252663 39402523 - TPX2 chr20 31739271 31801805 + SLC2A3 chr12 7919230 7936187 - DDX42 chr17 63773603 63819317 + SKA3 chr13 21153595 21176552 - PA2G4 chr12 56104537 56113910 + GOT2 chr16 58707131 58734342 - CENPV chr17 16342534 16353656 - TOMM7 chr7 22812628 22822852 - WBP4 chr13 41061509 41084006 + RPS9 chr19 54200809 54249003 + RPL37A chr2 216498825 216579180 + MT-CO2 chrMT 7586 8269 + MRPL43 chr10 100969458 100987515 - LAMA5 chr20 62307955 62367312 - VPS51 chr11 65089324 65111862 + GNAL chr18 11689264 11885685 + EEF1G chr11 62559596 62574086 - KLHDC2 chr14 49768130 49786385 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.