exRNAdisease

Entry Detail

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General Information

Database ID: exR0359253 RNA Name: ABHD8 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 17292131 End Site(bp): 17310236 External Links: ENSG00000127220

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ITM2C chr2 230864639 230879248 + TUBA3C chr13 19173772 19181824 - CAP1 chr1 40040233 40072649 + HOXB5 chr17 48591257 48593961 - RPLP2 chr11 809965 812880 + ARHGEF7 chr13 111114559 111305737 + NAP1L1 chr12 76036585 76084958 - DUSP2 chr2 96143169 96145440 - CHST11 chr12 104455295 104762014 + IGFBP2 chr2 216632828 216664436 + GALNS chr16 88813734 88856970 - RPS19 chr19 41860255 41872925 + PTMS chr12 6765516 6770952 + EMC10 chr19 50476400 50490870 + EIF4G2 chr11 10797050 10808940 - DDX17 chr22 38483438 38507660 - LRRC14 chr8 144517992 144525172 + PTK7 chr6 43076307 43161719 + FSTL1 chr3 120392293 120450993 - DNASE2 chr19 12875209 12881466 - ANXA11 chr10 80150889 80205572 - UCHL1 chr4 41256413 41268455 + S100A10 chr1 151982915 151993859 - CITED4 chr1 40861054 40862363 - DBN1 chr5 177456608 177474401 - PKM chr15 72199029 72231822 - MDK chr11 46380756 46383837 + GALNT17 chr7 71132144 71713600 + ZFP91 chr11 58579063 58621550 + RPS28 chr19 8321158 8323340 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC069281.2 chr7 100572232 100578700 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.