exRNAdisease

Entry Detail

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General Information

Database ID: exR0359259 RNA Name: ABL2 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 179099330 End Site(bp): 179229684 External Links: ENSG00000143322

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand FBXL19 chr16 30923055 30948783 + AC010422.3 chr19 12643831 12648397 - SRPK2 chr7 105110704 105399308 - KIAA0753 chr17 6578147 6640711 - WDR74 chr11 62832342 62841809 - RPL11 chr1 23691742 23696835 + DNAH1 chr3 52316319 52400491 + APBB3 chr5 140558268 140564781 - HECTD4 chr12 112160188 112382439 - RPS3 chr11 75399515 75422280 + ARPP19 chr15 52547045 52569883 - INPPL1 chr11 72223701 72239147 + LRWD1 chr7 102464956 102473168 + KPNA5 chr6 116681187 116741867 + RPL12 chr9 127447674 127451406 - KMT2D chr12 49018975 49059774 - UGDH chr4 39498755 39528311 - ZC4H2 chrX 64915802 65034713 - PTMA chr2 231706895 231713541 + PDPN chr1 13583465 13617957 + CHCHD10 chr22 23765834 23768443 - FUCA2 chr6 143494812 143511720 - TEAD3 chr6 35473597 35497079 - HNRNPM chr19 8444767 8489114 + ABL1 chr9 130713016 130887675 + GLUL chr1 182381704 182392206 - UBR4 chr1 19074510 19210266 - SSR2 chr1 156009048 156020951 - RPL13A chr19 49487554 49492308 + IMP4 chr2 130342877 130347967 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-154-5p chr14 101059769 101059790 + hsa-miR-188-5p chrX 50003517 50003537 + hsa-miR-339-5p chr7 1022990 1023012 - hsa-miR-625-5p chr14 65471116 65471136 + hsa-miR-425-5p chr3 49020199 49020221 - hsa-miR-532-3p chrX 50003204 50003225 + hsa-miR-1224-5p chr3 184241405 184241423 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand HIPK1-AS1 chr1 113924000 113929495 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.