exRNAdisease

Entry Detail

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General Information

Database ID: exR0359260 RNA Name: ABLIM1 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 114431113 End Site(bp): 114768061 External Links: ENSG00000099204

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDH1 chr16 68737292 68835541 + SMIM14 chr4 39546336 39638902 - SLC39A7 chr6 33200445 33204439 + COA6 chr1 234373456 234385068 + EEF2 chr19 3976056 3985463 - ZNF529 chr19 36534774 36605276 - PRRC2B chr9 131373636 131500197 + GAPDH chr12 6534512 6538374 + BTBD10 chr11 13388001 13463297 - EIF4B chr12 53006158 53042209 + MT-CO1 chrMT 5904 7445 + MT-ND1 chrMT 3307 4262 + CCNK chr14 99481169 99535044 + CRTAP chr3 33114014 33147773 + DDX47 chr12 12813316 12829981 + HSP90AA1 chr14 102080738 102139699 - MT-CO3 chrMT 9207 9990 + ACTR1A chr10 102461881 102502712 - HLA-B chr6 31269491 31357188 - EIF3E chr8 108201216 108435333 - BTG2 chr1 203305491 203309602 + RPS7 chr2 3575260 3580920 + P4HB chr17 81843161 81860624 - GNAI3 chr1 109548615 109600195 + TRIR chr19 12730640 12734684 - ANAPC11 chr17 81890790 81900991 + WBP11 chr12 14784582 14803486 - MRPS7 chr17 75261674 75266376 + ALAS1 chr3 52198086 52214327 + ZNF189 chr9 101398873 101410660 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3136-3p chr3 69048966 69048987 - hsa-miR-7111-3p chr6 35470558 35470579 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MAPKAPK5-AS1 chr12 111839764 111842902 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.