exRNAdisease

Entry Detail

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General Information

Database ID: exR0359269 RNA Name: ABTB2 RNA Type: mRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 34150987 End Site(bp): 34358010 External Links: ENSG00000166016

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACAA2 chr18 49782164 49813953 - AL136454.1 chr1 192716132 192716653 + ATE1 chr10 121740421 121928801 - CEP104 chr1 3812086 3857214 - CYP4X1 chr1 47023669 47050751 + ECE1 chr1 21217247 21345572 - EEF2 chr19 3976056 3985463 - FAM118A chr22 45308968 45341955 + FASN chr17 82078338 82098294 - GAPDH chr12 6534512 6538374 + ID3 chr1 23557926 23559501 - KRAS chr12 25205246 25250936 - NPAT chr11 108157215 108222638 - PDIA4 chr7 149003062 149028662 - PHC3 chr3 170086732 170181749 - PTTG1IP chr21 44849585 44873903 - RAB1B chr11 66268590 66277492 + RBBP4 chr1 32651142 32686211 + RPL22 chr1 6185020 6209389 - RPS18 chr6 33272075 33276511 + RUSC1 chr1 155320894 155331114 + SERP1 chr3 150541998 150603228 - SHISA5 chr3 48467798 48504826 - SRGN chr10 69088103 69104805 + SRP68 chr17 76038775 76072517 - STAT6 chr12 57095408 57132139 - TBC1D2B chr15 77984036 78077724 - TUBB chr6 30720352 30725426 + TWNK chr10 100987367 100994403 + ZFYVE9 chr1 52142094 52346686 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AP003392.4 chr11 119065263 119065677 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.