exRNAdisease

Entry Detail

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General Information

Database ID: exR0359275 RNA Name: ACAD11 RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 132558138 End Site(bp): 132660082 External Links: ENSG00000240303

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NPHP3-ACAD11 chr3 132558142 132722459 - BET1L chr11 167784 207428 - P4HB chr17 81843161 81860624 - STIM1 chr11 3854527 4093210 + HLA-DQA1 chr6 32628179 32647062 + FAR1 chr11 13668668 13732346 + PUM2 chr2 20248691 20352234 - TCIRG1 chr11 68039025 68050895 + PIK3C2A chr11 17077730 17207983 - PRPF8 chr17 1650629 1684867 - RPS8 chr1 44775251 44778779 + HADH chr4 107989714 108035175 + ZNF311 chr6 28994785 29005316 - MDN1 chr6 89642498 89819794 - PPOX chr1 161166056 161178013 + CD52 chr1 26317958 26320523 + RPL12 chr9 127447674 127451406 - PMF1 chr1 156212993 156240042 + HSPA9 chr5 138553756 138575416 - SH3PXD2B chr5 172325000 172454525 - CACNA2D3 chr3 54122547 55074557 + TK1 chr17 78174091 78187233 - DNAJB1 chr19 14514769 14529770 - ATP5IF1 chr1 28236109 28246906 + NBDY chrX 56729241 56819179 + RABGAP1L chr1 174159410 174995308 + ZNF146 chr19 36214602 36238774 + EHMT2 chr6 31879759 31897687 - SGTB chr5 65665928 65723035 - MTHFD2 chr2 74198610 74217565 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.