exRNAdisease

Entry Detail

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General Information

Database ID: exR0359277 RNA Name: ACAD9 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 128879596 End Site(bp): 128916067 External Links: ENSG00000177646

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP5F1E chr20 59025475 59032345 - AC138811.2 chr16 18788063 18801519 - GNA12 chr7 2728105 2844308 - MAVS chr20 3846799 3876123 + TGS1 chr8 55773446 55826445 + RPS4X chrX 72255679 72277248 - CABIN1 chr22 24011192 24178628 + SLC30A9 chr4 41990502 42090461 + SRSF7 chr2 38743599 38751494 - RPS13 chr11 17074388 17077715 - MIB2 chr1 1615415 1630610 + EDARADD chr1 236348257 236502915 + ARFIP1 chr4 152779937 152918463 + EI24 chr11 125569280 125584684 + RPS25 chr11 119015712 119018691 - GTF3C2 chr2 27325849 27357034 - ATP6V1F chr7 128862856 128865847 + SLC36A1 chr5 151437046 151492379 + RBMX chrX 136848004 136880764 - MT-ND2 chrMT 4470 5511 + B2M chr15 44711487 44718877 + TOB1 chr17 50862223 50867978 - ZNF551 chr19 57681969 57717301 + PEBP1 chr12 118136124 118145584 + ATP5MC2 chr12 53632726 53677408 - EEF2 chr19 3976056 3985463 - VIPAS39 chr14 77426675 77457952 - SLC18A2 chr10 117241093 117279430 + MID1IP1 chrX 38801432 38806537 + SNRNP200 chr2 96274338 96321271 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.