exRNAdisease

Entry Detail

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General Information

Database ID: exR0359279 RNA Name: ACADM RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 75724347 End Site(bp): 75787575 External Links: ENSG00000117054

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DBN1 chr5 177456608 177474401 - HMGA1 chr6 34236873 34246231 + ARID5A chr2 96536743 96552634 + RPN2 chr20 37178410 37241619 + HACD3 chr15 65530418 65578349 + ITGB3BP chr1 63440770 63593721 - HYOU1 chr11 119044188 119057227 - SLC35G1 chr10 93893973 93956062 + RBMXL1 chr1 88979456 88992960 - DTX4 chr11 59171430 59208588 + FOXN2 chr2 48314637 48379295 + PNN chr14 39175183 39183220 + BUB1B chr15 40161023 40221136 + DDX39B chr6 31530219 31542448 - GDI2 chr10 5765223 5842132 - FTL chr19 48965309 48966879 + PKM chr15 72199029 72231822 - SRRM1 chr1 24631716 24673281 + EXOSC8 chr13 36998816 37009614 + DHX8 chr17 43483865 43610338 + TRPC4 chr13 37636636 37870425 - POLDIP3 chr22 42583721 42614962 - RPL30 chr8 98024851 98046469 - COA7 chr1 52684449 52698347 - DNMT3B chr20 32762385 32809356 + ATP6V1G2-DDX39B chr6 31530219 31546608 - RPS24 chr10 78033760 78056813 + NR1H2 chr19 50329653 50383388 + NCOA4 chr10 46005088 46030714 - XPO1 chr2 61477849 61538626 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004812.2 chr12 120116907 120119000 + AC009948.2 chr2 178548884 178550681 + AC069287.1 chr11 112967 125927 - AL831711.1 chr1 161433444 161440996 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.