exRNAdisease

Entry Detail

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General Information

Database ID: exR0359281 RNA Name: ACADVL RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 7217125 End Site(bp): 7225266 External Links: ENSG00000072778

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand VKORC1 chr16 31090842 31095980 - EIF2S1 chr14 67360151 67386516 + OAF chr11 120211032 120230334 + TXN2 chr22 36467046 36481640 - LRRC8A chr9 128882112 128918039 + ALKBH4 chr7 102456238 102464863 - IGF2BP2 chr3 185643739 185825056 - TMED7 chr5 115613210 115632992 - ZNF782 chr9 96816269 96875623 - RRP1B chr21 43659560 43696079 + ERI3 chr1 44221070 44355260 - RAN chr12 130872037 130877678 + PXDN chr2 1631887 1744852 - PLEKHG4B chr5 92151 189972 + B2M chr15 44711487 44718877 + RBM8A chr1 145917714 145927678 - ZNRF2 chr7 30284597 30367689 + SLC29A1 chr6 44219553 44234142 + CANX chr5 179678628 179731641 + ZFP36L1 chr14 68787660 68796253 - RBM23 chr14 22893204 22919182 - EMP3 chr19 48321509 48330553 + WDSUB1 chr2 159235793 159286799 - GSTP1 chr11 67583742 67586656 + FAM102A chr9 127940582 127980989 - UQCRHL chr1 15807169 15809348 - CD70 chr19 6583183 6604103 - GOPC chr6 117560269 117602542 - RIPOR1 chr16 67518418 67546788 + POLDIP3 chr22 42583721 42614962 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC098850.4 chr17 16788057 16816540 + AD000090.1 chr19 35557956 35581954 + PCAT14 chr22 23536881 23547797 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.