exRNAdisease

Entry Detail

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General Information

Database ID: exR0359283 RNA Name: ACAP1 RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 7336529 End Site(bp): 7351477 External Links: ENSG00000072818

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HLA-DRA chr6 32439878 32445046 + FOXH1 chr8 144473412 144475849 - ZNF449 chrX 135344796 135363413 + MIF chr22 23894383 23895227 + KDF1 chr1 26949562 26960468 - SQSTM1 chr5 179806398 179838078 + PFN1 chr17 4945652 4949061 - CD74 chr5 150400041 150412929 - RGS10 chr10 119499817 119542719 - TUBB chr6 30720352 30725426 + ISG15 chr1 1001138 1014540 + C20orf204 chr20 64034344 64039962 + AL133352.1 chr10 100505628 100529881 - DHX16 chr6 30653119 30673006 - AP002990.1 chr11 62559603 62591531 - UGCG chr9 111896814 111935369 + DNAJC30 chr7 73680918 73683453 - ACTG1 chr17 81509971 81523847 - VPS53 chr17 508668 721717 - HLA-DMA chr6 32948613 32969094 - CDC25B chr20 3786772 3806121 + RCC1 chr1 28505943 28539300 + YME1L1 chr10 27110112 27155266 - REEP3 chr10 63521401 63625128 + CD70 chr19 6583183 6604103 - ZNF593 chr1 26169908 26170873 + NSMF chr9 137447573 137459334 - EXOC3 chr5 443175 471937 + ZNF761 chr19 53445001 53458261 + APH1A chr1 150265399 150269580 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC139149.1 chr17 81514047 81527776 + LINC01184 chr5 127939152 128083172 - SNHG3 chr1 28505980 28510892 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.