exRNAdisease

Entry Detail

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General Information

Database ID: exR0359285 RNA Name: ACAP3 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 1292390 End Site(bp): 1309609 External Links: ENSG00000131584

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IMP3 chr15 75639085 75648706 - TAOK2 chr16 29973868 29992261 + SDCBP chr8 58552924 58582859 + NUP62 chr19 49906825 49929763 - ALG1 chr16 5033923 5087379 + EEF2 chr19 3976056 3985463 - S100A13 chr1 153618787 153631360 - RUNX3 chr1 24899511 24965121 - SLC15A4 chr12 128793194 128823958 - HAND1 chr5 154474972 154478227 - MTOR chr1 11106535 11262551 - SENP3 chr17 7561919 7571969 + MIF chr22 23894383 23895227 + SLC7A5 chr16 87830023 87869507 - MT-ND4 chrMT 10760 12137 + DEPDC5 chr22 31753867 31908033 + SLC27A2 chr15 50182196 50236385 + XPO6 chr16 28097979 28211920 - PCSK1N chrX 48831096 48835610 - KMT2B chr19 35717973 35738878 + MCM3AP chr21 46235133 46286297 - PFKM chr12 48105139 48146404 + TUBA4A chr2 219249710 219278170 - CLTC chr17 59619689 59696956 + PIK3C2B chr1 204422628 204494724 - TRIM7 chr5 181193924 181205293 - HIRA chr22 19330698 19447450 - AURKAIP1 chr1 1373730 1375495 - SETD1A chr16 30957754 30984664 + ZFHX4 chr8 76681239 76867281 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL157392.3 chr10 13631143 13668445 + AL355075.4 chr14 20343048 20343685 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.