exRNAdisease

Entry Detail

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General Information

Database ID: exR0359286 RNA Name: ACAT1 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 108116695 End Site(bp): 108147603 External Links: ENSG00000075239

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP2A2 chr12 110280756 110351093 + MTRNR2L8 chr11 10507894 10509186 - TRIP10 chr19 6737925 6751530 + NPEPPS chr17 47522942 47623276 + DAPK1 chr9 87497228 87708634 + PSMB5 chr14 23016543 23035230 - CCDC102A chr16 57512181 57536571 - FZD3 chr8 28494205 28574267 + NCAM1 chr11 112961247 113278436 + PRDX4 chrX 23664262 23686397 + PSMD10 chrX 108084207 108091549 - PGK1 chrX 77910739 78129295 + HSP90AB1 chr6 44246166 44253888 + NPIPB2 chr16 11927259 11976643 - TXNRD1 chr12 104215779 104350307 + MRPL47 chr3 179588285 179604649 - AC010422.3 chr19 12643831 12648397 - GHITM chr10 84139509 84153568 + POU3F3 chr2 104853287 104858574 + RPS4X chrX 72255679 72277248 - DAP3 chr1 155687960 155739010 + EEF1A1 chr6 73515750 73523797 - GLI2 chr2 120735623 120992653 + IER3IP1 chr18 47152834 47176364 - RPLP1 chr15 69452814 69456205 + ACTG1 chr17 81509971 81523847 - IGFBP2 chr2 216632828 216664436 + NUP205 chr7 135557917 135648757 + ACTB chr7 5527148 5563784 - TXNDC16 chr14 52430596 52552522 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MIR155HG chr21 25561909 25575168 + POLR2J4 chr7 43940895 44019175 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.