exRNAdisease

Entry Detail

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General Information

Database ID: exR0359287 RNA Name: ACAT2 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 159762045 End Site(bp): 159779112 External Links: ENSG00000120437

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RIMS3 chr1 40620680 40665682 - RPL13 chr16 89560657 89566828 + ATP5MC2 chr12 53632726 53677408 - TTF2 chr1 117060326 117107453 + FAM83F chr22 39994954 40043534 + TMEM14C chr6 10722915 10731129 + PWP2 chr21 44107373 44131181 + CINP chr14 102341102 102362916 - FKBP8 chr19 18531751 18544077 - PFN1 chr17 4945652 4949061 - HDAC11 chr3 13479724 13506424 + RIOX1 chr14 73490933 73493394 + HSF1 chr8 144291591 144314720 + SLC7A3 chrX 70925579 70931125 - RPS13 chr11 17074388 17077715 - ALG12 chr22 49900229 49918438 - SKIL chr3 170357678 170396835 + BTG1 chr12 92140278 92145846 - FDPS chr1 155308748 155320666 + ZCCHC10 chr5 132996985 133026604 - IFT27 chr22 36758202 36776256 - SURF2 chr9 133356550 133361158 + COX6B1 chr19 35648323 35658782 + ZNF451 chr6 57086844 57170305 + RPL30 chr8 98024851 98046469 - MLYCD chr16 83899115 83951445 + HAUS4 chr14 22946228 22957161 - RPL37 chr5 40825262 40835222 - MTRNR2L11 chr1 237943724 237945275 - KDM4A chr1 43650149 43705518 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + AL158835.3 chr10 125707416 125749525 - HCP5 chr6 31463170 31478936 + PRNCR1 chr8 127079874 127092600 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.