exRNAdisease

Entry Detail

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General Information

Database ID: exR0359288 RNA Name: ACBD3 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 226144679 End Site(bp): 226186741 External Links: ENSG00000182827

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MTRNR2L12 chr3 96617188 96618236 - SLC16A2 chrX 74421493 74533917 + RPS24 chr10 78033760 78056813 + NUSAP1 chr15 41320794 41381050 + LRWD1 chr7 102464956 102473168 + S1PR4 chr19 3172346 3180332 + RSU1 chr10 16590611 16817463 - RPL15 chr3 23916545 23924374 + FOCAD chr9 20658309 20995955 + GPR176 chr15 39799008 39920266 - RAPGEF1 chr9 131576770 131740074 - UTP18 chr17 51260546 51297936 + LIMCH1 chr4 41359607 41700044 + ZNF224 chr19 44094339 44109886 + TTC39C chr18 23992773 24135610 + IGFBP5 chr2 216672105 216695549 - YTHDF1 chr20 63195429 63216139 - RGS10 chr10 119499817 119542719 - CFL1 chr11 65823022 65862026 - TPT1 chr13 45333471 45341370 - RASGRP2 chr11 64726911 64745456 - ACLY chr17 41866917 41930542 - UQCRQ chr5 132866630 132868847 + ID4 chr6 19837370 19842197 + CSNK1E chr22 38290691 38318084 - PUM1 chr1 30931506 31065991 - ZBTB33 chrX 120250752 120258398 + TSN chr2 121737103 121767853 + HK1 chr10 69269984 69401884 + DNPEP chr2 219373527 219400022 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009404.1 chr2 117833937 117841658 + AC023908.2 chr15 39770559 39801333 - AL022311.1 chr22 37876148 37895563 + AL513314.2 chr1 222477252 222504622 - MIR663AHG chr20 26167817 26251546 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.