exRNAdisease

Entry Detail

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General Information

Database ID: exR0359289 RNA Name: ACBD4 RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 45132600 End Site(bp): 45144181 External Links: ENSG00000181513

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANP32A chr15 68778535 68820897 - BSG chr19 571277 583493 + CCDC6 chr10 59788747 59906556 - CDON chr11 125955796 126063335 - DYNLL2 chr17 58083419 58095542 + EIF3C chr16 28688558 28735730 + ENO1 chr1 8861000 8879190 - GAPDH chr12 6534512 6538374 + GATAD1 chr7 92447482 92460075 + HPN chr19 35040506 35066571 + KAT7 chr17 49788681 49835026 + LIN28A chr1 26410817 26429728 + LRP4 chr11 46856717 46918642 - MAD2L2 chr1 11674480 11691650 - PDE4D chr5 58969038 60522120 - PDHB chr3 58427630 58433857 - PPP6R1 chr19 55229779 55259017 - SCAND1 chr20 35953617 35959472 - TMA16 chr4 163494442 163520539 + TPM3 chr1 154155304 154194648 - TPRN chr9 137191617 137204193 - TSR1 chr17 2322396 2336657 - TUBA1B chr12 49127782 49131397 - USP39 chr2 85602856 85649283 + VPS26C chr21 37223420 37267919 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC027290.2 chr12 122865335 122867021 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.