exRNAdisease

Entry Detail

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General Information

Database ID: exR0359290 RNA Name: ACBD5 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 27195214 End Site(bp): 27242130 External Links: ENSG00000107897

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDC42SE1 chr1 151050971 151070325 - MAML3 chr4 139716753 140154184 - TUBA1C chr12 49188736 49274603 + RPL13A chr19 49487554 49492308 + MAP4K2 chr11 64784918 64803241 - PTCD1 chr7 99416739 99466163 - ATP5MF-PTCD1 chr7 99419749 99466197 - HSPA8 chr11 123057489 123063230 - GGA2 chr16 23463542 23521995 - TUBA1A chr12 49184795 49189080 - TMEM216 chr11 61392360 61398863 + YLPM1 chr14 74763316 74859435 + AMOT chrX 112774503 112840815 - IGF2 chr11 2129112 2141238 - PLS1 chr3 142596393 142713664 + DECR2 chr16 401858 412487 + TPI1 chr12 6867119 6870948 + RNF7 chr3 141738249 141747560 + ENO1 chr1 8861000 8879190 - RTN3 chr11 63681446 63759891 + MYL12B chr18 3261479 3278431 + B2M chr15 44711487 44718877 + LRIG2 chr1 113073198 113132260 + CKAP5 chr11 46743048 46846308 - RPS24 chr10 78033760 78056813 + GOT2 chr16 58707131 58734342 - HIPK3 chr11 33256672 33357023 + FTL chr19 48965309 48966879 + LCP1 chr13 46125920 46211871 - NACA2 chr17 61590421 61591219 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-93-5p chr7 100093815 100093837 - hsa-miR-145-5p chr5 149430661 149430683 + hsa-miR-526b-5p chr19 53694406 53694428 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020916.1 chr19 13823880 13842928 - AC132217.1 chr11 2129121 2129964 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.