exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359291 RNA Name: ACBD6 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 180269653 End Site(bp): 180502954 External Links: ENSG00000230124

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TMEM187 chrX 153972754 153983194 + SIGMAR1 chr9 34634722 34637809 - COPS7A chr12 6724014 6731875 + SPTLC3 chr20 13008972 13169103 + BLOC1S1 chr12 55716037 55720087 + TOB2 chr22 41433494 41446801 - ACAP3 chr1 1292390 1309609 - AC011455.2 chr19 38915404 38949855 - TUBA1A chr12 49184795 49189080 - GLTP chr12 109850945 109880541 - FBXO17 chr19 38941401 38975742 - CMTM4 chr16 66614750 66696707 - AC055811.2 chr17 17202649 17237185 - PHACTR4 chr1 28369582 28500364 + NUDT15 chr13 48037726 48047221 + ADGRL1 chr19 14147743 14206187 - RER1 chr1 2391775 2405442 + EIF4H chr7 74174245 74197101 + MAFK chr7 1530702 1543043 + PLXNA3 chrX 154458281 154477779 + TOMM40 chr19 44890569 44903689 + HAUS1 chr18 46104378 46128333 + INPP5A chr10 132537787 132783480 + FTL chr19 48965309 48966879 + HINFP chr11 119121580 119136059 + MT-CO2 chrMT 7586 8269 + TUBB chr6 30720352 30725426 + SEH1L chr18 12947133 12987536 + VCP chr9 35056064 35072627 - B3GNT5 chr3 183253253 183298504 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL121992.1 chr1 15586136 15603626 - AL121987.1 chr1 160062461 160080769 + AL645608.2 chr1 911435 914948 + MALAT1 chr11 65497688 65506516 + SLC16A1-AS1 chr1 112956415 113047055 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.