exRNAdisease

Entry Detail

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General Information

Database ID: exR0359292 RNA Name: ACBD7 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 15075475 End Site(bp): 15088776 External Links: ENSG00000176244

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATXN3 chr14 92044496 92106621 - CNMD chr13 52703264 52739820 - CTSB chr8 11842524 11869448 - PCDHA1 chr5 140786136 141012347 + PCDHA10 chr5 140855883 141012347 + PCDHA11 chr5 140868183 141012344 + PCDHA12 chr5 140875302 141012347 + PCDHA13 chr5 140882124 141012347 + PCDHA2 chr5 140794852 141012347 + PCDHA3 chr5 140801028 141012347 + PCDHA4 chr5 140806929 141012347 + PCDHA5 chr5 140821604 141012347 + PCDHA6 chr5 140827958 141012347 + PCDHA7 chr5 140834248 141012347 + PCDHA8 chr5 140841187 141012347 + PCDHA9 chr5 140847463 141012344 + PCDHAC1 chr5 140926369 141012344 + PCDHAC2 chr5 140966470 141012347 + PGAM1 chr10 97426191 97433444 + RBM25 chr14 73058532 73123899 + TAF6 chr7 100107070 100119841 - ZNF320 chr19 52860851 52897693 - ZNF346 chr5 177022696 177081189 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.