exRNAdisease

Entry Detail

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General Information

Database ID: exR0359295 RNA Name: ACER3 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 76860867 End Site(bp): 77026797 External Links: ENSG00000078124

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLC39A13 chr11 47407132 47416496 + HLA-A chr6 29941260 29945884 + BANP chr16 87949244 88077318 + ARCN1 chr11 118572390 118603033 + PPIB chr15 64155812 64163205 - NDUFC2-KCTD14 chr11 78016971 78079865 - CCT2 chr12 69585426 69601570 + PTRH2 chr17 59674636 59707626 - TBC1D4 chr13 75283503 75482169 - NDUFC2 chr11 78068297 78079862 - KLHL7 chr7 23105758 23177914 + EIF3C chr16 28688558 28735730 + DNAJB6 chr7 157335381 157417439 + RPS10-NUDT3 chr6 34284887 34426071 - RPS10 chr6 34417454 34426069 - C22orf39 chr22 19351368 19448232 - MRFAP1L1 chr4 6707701 6709865 - SLC3A2 chr11 62856102 62888875 + TSKU chr11 76782251 76798153 + DPH1 chr17 2030110 2043430 + SYAP1 chrX 16719612 16765340 + HNRNPH1 chr5 179614178 179634784 - SHMT2 chr12 57229573 57234935 + RPL27A chr11 8682788 8714759 + FAM3C chr7 121348878 121396364 - PRDX3 chr10 119167720 119178812 - CNN2 chr19 1026586 1039068 + NOTCH2 chr1 119911553 120100779 - CDC42SE2 chr5 131245493 131398447 + AC010422.3 chr19 12643831 12648397 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-27a-3p chr19 13836447 13836467 - hsa-miR-129-5p chr7 128207876 128207896 + hsa-miR-27b-3p chr9 95085505 95085525 + circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.