exRNAdisease

Entry Detail

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General Information

Database ID: exR0359299 RNA Name: ACO2 RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41469117 End Site(bp): 41528989 External Links: ENSG00000100412

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RASA4 chr7 102573807 102616757 - NOC2L chr1 944203 959309 - RPS17 chr15 82536750 82540459 - LAMA1 chr18 6941742 7117797 - DPYSL2 chr8 26514031 26658178 + MTIF2 chr2 55236595 55269347 - EDIL3 chr5 83940554 84384880 - NAMPT chr7 106248298 106286326 - CDH1 chr16 68737292 68835541 + AP002990.1 chr11 62559603 62591531 - DDX19B chr16 70289663 70335283 + IFITM1 chr11 313506 315272 + COMT chr22 19941733 19969975 + R3HDM2 chr12 57253762 57431005 - HNRNPK chr9 83968083 83980616 - TMBIM6 chr12 49707725 49764934 + TUBB chr6 30720352 30725426 + U2AF1L5 chr21 6484623 6499261 - WDR74 chr11 62832342 62841809 - IQCB1 chr3 121769761 121835079 - KIF26A chr14 104138723 104180894 + CDCA2 chr8 25459199 25507911 + RRP36 chr6 43021623 43034156 + PTPRS chr19 5158495 5340803 - HDGFL3 chr15 83112738 83207823 - DAP chr5 10679230 10761272 - CD52 chr1 26317958 26320523 + PSMA2 chr7 42916861 42932185 - COPG1 chr3 129249606 129277773 + FRMPD4 chrX 11822423 12724523 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079781.5 chr7 97851688 97972985 - AC147651.4 chr7 603185 608482 + AC245033.4 chr15 82533175 82540008 - SNHG19 chr16 2154797 2155358 - SNHG7 chr9 136721366 136728184 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.