exRNAdisease

Entry Detail

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General Information

Database ID: exR0359304 RNA Name: ACOT2 RNA Type: mRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 73567620 End Site(bp): 73575658 External Links: ENSG00000119673

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACOT1 chr14 73537143 73543796 + ACOT4 chr14 73591706 73596496 + ACOT6 chr14 73610945 73619888 + ACSL4 chrX 109624244 109733403 - AL136295.5 chr14 24147548 24166452 + ANKRD16 chr10 5861616 5889906 - CRABP2 chr1 156699606 156705816 - ESYT2 chr7 158730995 158830253 - GOT2 chr16 58707131 58734342 - LIN28A chr1 26410817 26429728 + MRPL4 chr19 10251901 10260055 + MRPS10 chr6 42206807 42217861 - MUC4 chr3 195746765 195811973 - NBN chr8 89933336 90003228 - PARK7 chr1 7954291 7985505 + RNF130 chr5 179911651 180072113 - RNF31 chr14 24146683 24160660 + RPL18 chr19 48615328 48619184 - RPS9 chr19 54200809 54249003 + SDC3 chr1 30869466 30908758 - SDHAF4 chr6 70566917 70589569 + SEMA5B chr3 122909082 123028605 - SIGIRR chr11 405716 417455 - SIVA1 chr14 104753147 104768494 + TARDBP chr1 11012344 11026420 + TMEM259 chr19 1009648 1021179 - TSC22D4 chr7 100463359 100479232 - TTI1 chr20 37983007 38033461 - UBC chr12 124911604 124917368 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.