exRNAdisease

Entry Detail

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General Information

Database ID: exR0359305 RNA Name: ACOT8 RNA Type: mRNA Chromosome: chr20 Starnd: - Coordinate: Start Site(bp): 45841721 End Site(bp): 45857405 External Links: ENSG00000101473

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BAHD1 chr15 40439721 40468236 + RPS14 chr5 150442635 150449739 - C19orf53 chr19 13774456 13778773 + B2M chr15 44711487 44718877 + CHST15 chr10 124007668 124093598 - HAUS7 chrX 153447666 153495516 - CANX chr5 179678628 179731641 + SRPK2 chr7 105110704 105399308 - SZRD1 chr1 16352575 16398145 + CCL3 chr17 36088256 36090169 - HVCN1 chr12 110627841 110704950 - MAP7D1 chr1 36155579 36180849 + VMP1 chr17 59707192 59842255 + NCF4 chr22 36860988 36878017 + WBP1 chr2 74458400 74460891 + SBK1 chr16 28259246 28323849 + SLC16A1 chr1 112911847 112957013 - ARPC4 chr3 9792495 9807726 + CIC chr19 42268537 42295797 + PPP2R5C chr14 101761798 101927989 + CDK2 chr12 55966781 55972789 + GCSAM chr3 112120839 112133270 - EP400 chr12 131949942 132080460 + ABCD4 chr14 74285269 74303055 - RPL27A chr11 8682788 8714759 + PYURF chr4 88520998 88523776 - SAP18 chr13 21140514 21149084 + H6PD chr1 9234775 9271337 + NOP53 chr19 47745546 47757058 + TRIM45 chr1 117111060 117122587 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand BX890604.2 chrX 3817528 3937855 - MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.