exRNAdisease

Entry Detail

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General Information

Database ID: exR0359310 RNA Name: ACP1 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 264140 End Site(bp): 278283 External Links: ENSG00000143727

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PIP4K2A chr10 22534854 22714578 - XPO6 chr16 28097979 28211920 - UBP1 chr3 33388336 33441371 - CST3 chr20 23626706 23638473 - RPS4X chrX 72255679 72277248 - ENSA chr1 150600851 150629612 - PTOV1 chr19 49850735 49860744 + SMC5 chr9 70258978 70354873 + TUFM chr16 28842411 28846348 - DTD2 chr14 31446036 31457506 - B2M chr15 44711487 44718877 + NUDT5 chr10 12165330 12196144 - SCD chr10 100347233 100364826 + VSIG10 chr12 118063593 118136026 - TBX6 chr16 30085793 30091887 - AC009133.6 chr16 29812261 29820092 + BORCS5 chr12 12357078 12471233 + ARPC2 chr2 218217141 218254356 + TOP2A chr17 40388525 40417896 - MT-CO1 chrMT 5904 7445 + EIF3CL chr16 28379579 28403879 - EIF3H chr8 116642130 116766925 - POLH chr6 43576185 43620523 + TUBB chr6 30720352 30725426 + CHMP1A chr16 89644435 89657721 - MOB3A chr19 2071036 2096673 - LYRM4 chr6 5102593 5260939 - TP53 chr17 7661779 7687550 - ORMDL3 chr17 39921041 39927601 - MSH2 chr2 47403067 47663146 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7b-5p chr22 46113691 46113712 + hsa-let-7d-5p chr9 94178841 94178862 + hsa-let-7f-5p chrX 53557246 53557267 - hsa-miR-196a-5p chr17 48632532 48632553 - hsa-let-7g-5p chr3 52268336 52268357 - hsa-let-7i-5p chr12 62603691 62603712 + hsa-miR-151a-3p chr8 140732587 140732607 - hsa-miR-196b-5p chr7 27169528 27169549 - hsa-miR-519c-5p chr19 53686484 53686505 + hsa-miR-519b-5p chr19 53695225 53695246 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC126365.1 chr17 20788071 20789584 + AL139819.1 chr10 100335563 100346390 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.