exRNAdisease

Entry Detail

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General Information

Database ID: exR0359311 RNA Name: ACP5 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 11574660 End Site(bp): 11579008 External Links: ENSG00000102575

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACTG1 chr17 81509971 81523847 - AL669918.1 chr6 32813767 32838822 - ATP5F1D chr19 1241746 1244825 + B2M chr15 44711487 44718877 + CCT3 chr1 156308968 156367873 - CD226 chr18 69831158 69961803 - COX4I1 chr16 85798633 85807068 + COX6C chr8 99873200 99893707 - ENO1 chr1 8861000 8879190 - GALNT6 chr12 51351247 51392867 - HLA-B chr6 31269491 31357188 - IRAK1 chrX 154010506 154019902 - LTA chr6 31572054 31574324 + NCAPD2 chr12 6493356 6531955 + NME3 chr16 1770286 1771730 - PFN1 chr17 4945652 4949061 - PPP4R3B chr2 55547292 55618880 - PRR7 chr5 177446445 177456286 + RBM33 chr7 155644451 155781485 + RNASET2 chr6 166929504 166957191 - RPL4 chr15 66498015 66524532 - SLC25A6 chrX 1386152 1392113 - SMAD2 chr18 47808957 47931146 - SNRNP40 chr1 31259568 31296788 - TAP2 chr6 32821833 32838770 - TERF2IP chr16 75647773 75761872 + UBC chr12 124911604 124917368 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand SNHG16 chr17 76557764 76565348 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.