exRNAdisease

Entry Detail

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General Information

Database ID: exR0359317 RNA Name: ACSF3 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 89088375 End Site(bp): 89164121 External Links: ENSG00000176715

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand REXO1 chr19 1815248 1848483 - PBX1 chr1 164555584 164899296 + RBFOX2 chr22 35738736 36028824 - FAM193B chr5 177519789 177554563 - SLC47A1 chr17 19495385 19579034 + ATG2A chr11 64894546 64917211 - TP63 chr3 189631389 189897276 + ARID1A chr1 26693236 26782104 + SBNO2 chr19 1107637 1174268 - AKT2 chr19 40230317 40285536 - LRRC14 chr8 144517992 144525172 + DGKD chr2 233354507 233472104 + SATB1 chr3 18345377 18445588 - DCTD chr4 182890060 182917936 - NHSL1 chr6 138422043 138692571 - SOX4 chr6 21593751 21598619 + ZNF227 chr19 44207547 44237268 + FAM189B chr1 155247205 155255483 - PAK4 chr19 39125770 39182816 + SNRPB chr20 2461634 2470853 - RPL18A chr19 17859910 17864153 + NDUFV2 chr18 9102630 9134345 + ABR chr17 1003518 1229738 - TANGO2 chr22 20017014 20067164 + BPTF chr17 67825503 67984378 + UBA52 chr19 18571730 18577550 + SYAP1 chrX 16719612 16765340 + ADAR chr1 154582057 154628013 - TXNL1 chr18 56597209 56651600 - NUP153 chr6 17615035 17706834 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AP005263.1 chr18 9102736 9254346 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.