exRNAdisease

Entry Detail

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General Information

Database ID: exR0359326 RNA Name: ACSS1 RNA Type: mRNA Chromosome: chr20 Starnd: - Coordinate: Start Site(bp): 25006230 End Site(bp): 25058980 External Links: ENSG00000154930

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CTSB chr8 11842524 11869448 - RPL13 chr16 89560657 89566828 + RPL3 chr22 39312882 39320389 - MX1 chr21 41420304 41459214 + MKI67 chr10 128096659 128126423 - PTK2B chr8 27311482 27459391 + CLPTM1L chr5 1317752 1345099 - DIMT1 chr5 62347284 62403939 - LCP1 chr13 46125920 46211871 - CD79A chr19 41877279 41881372 + CMC4 chrX 155061622 155071136 - PHC3 chr3 170086732 170181749 - SASH3 chrX 129779949 129795201 + PAICS chr4 56435741 56464579 + PGM2 chr4 37826660 37862937 + MTRNR2L8 chr11 10507894 10509186 - AC092073.1 chr19 34396315 34409364 + ARL6IP6 chr2 152717893 152761253 + RPS29 chr14 49570984 49599164 - MTCP1 chrX 155064034 155147937 - GPI chr19 34359480 34402413 + CASP8 chr2 201233443 201287711 + MSL3 chrX 11758159 11775772 + EEF2 chr19 3976056 3985463 - SFPQ chr1 35176378 35193145 - TNFRSF14 chr1 2555639 2565382 + ACAD8 chr11 134253495 134265855 + RPL14 chr3 40457292 40468587 + PPP2R1A chr19 52190048 52229518 + SYVN1 chr11 65121780 65134533 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.