exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359340 RNA Name: ACTR10 RNA Type: mRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 58200080 End Site(bp): 58235636 External Links: ENSG00000131966

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HIBCH chr2 190189735 190344193 - CCNG1 chr5 163437569 163446151 + PPP2CA chr5 134194332 134226073 - TOMM20 chr1 235109341 235128837 - ACTB chr7 5527148 5563784 - APP chr21 25880550 26171128 - PTK2B chr8 27311482 27459391 + CTDSP2 chr12 57819927 57846729 - SLC6A9 chr1 43991500 44031467 - B2M chr15 44711487 44718877 + RPS20 chr8 56067295 56074581 - NUDC chr1 26900238 26946871 + AURKA chr20 56369389 56392337 - PABPC3 chr13 25095868 25099254 + TUBA3C chr13 19173772 19181824 - UBA6 chr4 67612652 67701155 - CAND1 chr12 67269358 67319953 + MGRN1 chr16 4616493 4690974 + ARF1 chr1 228082660 228099212 + ALDOA chr16 30064164 30070457 + MTRNR2L12 chr3 96617188 96618236 - PBX1 chr1 164555584 164899296 + PRKCI chr3 170222424 170305977 + LRRC20 chr10 70298970 70382650 - CCNC chr6 99542387 99568825 - SMARCC1 chr3 47585269 47782106 - TSPAN15 chr10 69451465 69507666 + NID1 chr1 235975830 236065109 - CAMK2G chr10 73812501 73874591 - AIF1L chr9 131096476 131123152 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.