exRNAdisease

Entry Detail

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General Information

Database ID: exR0359356 RNA Name: ACY1 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 51983340 End Site(bp): 51989197 External Links: ENSG00000243989

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand INVS chr9 100099243 100302175 + PPP2R5E chr14 63371364 63543377 - SRSF1 chr17 58000919 58007346 - ANP32A chr15 68778535 68820897 - KDELR2 chr7 6445953 6484190 - OAS2 chr12 112978395 113011723 + ILF3 chr19 10654261 10692417 + SLC25A3 chr12 98593591 98606379 + ABCG2 chr4 88090150 88231628 - MAPK3 chr16 30114105 30123506 - TUBA1B chr12 49127782 49131397 - NEDD8 chr14 24216857 24232367 - ABHD14A-ACY1 chr3 51974706 51989183 + LASP1 chr17 38869859 38921770 + HERC1 chr15 63608618 63833948 - LRIG3 chr12 58872149 58920522 - TPI1 chr12 6867119 6870948 + ZNF623 chr8 143636013 143656418 + UBC chr12 124911604 124917368 - RPS3 chr11 75399515 75422280 + RBM38 chr20 57391396 57409333 + UCKL1 chr20 63939829 63956416 - PPTC7 chr12 110533245 110583318 - TRIM28 chr19 58544064 58550722 + RPLP0 chr12 120196699 120201235 - PABPN1 chr14 23321289 23326185 + GANAB chr11 62624826 62646726 - PLAT chr8 42174718 42207676 - TMEM184B chr22 38219291 38273010 - GNL3 chr3 52681156 52694497 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-625-5p chr14 65471116 65471136 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + DANCR chr4 52712404 52720351 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.