exRNAdisease

Entry Detail

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General Information

Database ID: exR0359363 RNA Name: ADAM11 RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 44758988 End Site(bp): 44781846 External Links: ENSG00000073670

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGRN chr1 1020120 1056118 + CREBZF chr11 85659708 85682908 - CSDE1 chr1 114716913 114758676 - FANCA chr16 89737549 89816657 - GHDC chr17 42188799 42194532 - GOLPH3 chr5 32124716 32174319 - HCFC1 chrX 153947557 153971818 - HDGFL3 chr15 83112738 83207823 - KIAA1841 chr2 61065871 61138034 + LMNB2 chr19 2427638 2456959 - LRP6 chr12 12116025 12267044 - MCC chr5 113022099 113488823 - MDC1 chr6 30699807 30717447 - MDGA1 chr6 37630679 37699306 - MT-ND1 chrMT 3307 4262 + NISCH chr3 52455118 52493068 + NOP53 chr19 47745546 47757058 + PLXNA1 chr3 126988594 127037392 + SF3B3 chr16 70523791 70577670 + SNX17 chr2 27370496 27377535 + TLE3 chr15 70047790 70098176 - TM9SF2 chr13 99446311 99564048 + TMEM25 chr11 118531041 118547280 + TNPO2 chr19 12699194 12724011 - TUBB chr6 30720352 30725426 + UNC119B chr12 120710458 120723640 + YBX1 chr1 42682418 42703805 + ZNF70 chr22 23738682 23751112 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC02228 chr5 25087450 25190956 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.