exRNAdisease

Entry Detail

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General Information

Database ID: exR0359365 RNA Name: ADAM15 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 155050566 End Site(bp): 155062775 External Links: ENSG00000143537

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NNT chr5 43602692 43707405 + PCSK1N chrX 48831096 48835610 - RBM26 chr13 79311824 79406477 - AC096887.1 chr3 52969119 53099453 - DSG2 chr18 31498177 31549008 + NR3C1 chr5 143277931 143435512 - SF3A2 chr19 2236824 2248655 + MKI67 chr10 128096659 128126423 - HDHD5 chr22 17137511 17165287 - VAMP7 chrX 155881345 155943769 + CBFB chr16 67028984 67101058 + DYNLL2 chr17 58083419 58095542 + KIFC1 chr6 33391823 33409896 + SIGMAR1 chr9 34634722 34637809 - MTRNR2L12 chr3 96617188 96618236 - CNOT9 chr2 218568580 218597080 + OTUD4 chr4 145110838 145180589 - ATG4B chr2 241637213 241673857 + WNK1 chr12 752579 911452 + LTBP1 chr2 32946953 33399509 + MTHFD1 chr14 64388031 64463457 + ALDOA chr16 30064164 30070457 + APEX1 chr14 20455191 20457772 + TNRC18 chr7 5306790 5425414 - HK1 chr10 69269984 69401884 + MARCKS chr6 113857345 113863475 + SETD6 chr16 58515479 58521181 + PAX9 chr14 36657568 36679362 + NEK6 chr9 124257606 124353307 + PCYOX1L chr5 149358037 149369653 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.