exRNAdisease

Entry Detail

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General Information

Database ID: exR0359366 RNA Name: ADAM17 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 9488486 End Site(bp): 9556732 External Links: ENSG00000151694

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ITM2C chr2 230864639 230879248 + HUNK chr21 31873020 32044633 + TPGS2 chr18 36777647 36829216 - MOCS3 chr20 50958818 50963929 + ESCO2 chr8 27771949 27812640 + COMMD1 chr2 61888724 62147247 + TMX1 chr14 51240162 51257655 + NACA chr12 56712427 56731628 - ELOVL5 chr6 53267398 53349179 - KHDRBS1 chr1 32013868 32060850 + PSMA2 chr7 42916861 42932185 - PTMA chr2 231706895 231713541 + GATAD1 chr7 92447482 92460075 + SLC30A9 chr4 41990502 42090461 + SUGP2 chr19 18990888 19034023 - CCT5 chr5 10249929 10266389 + RNF44 chr5 176526712 176538025 - ATP5MC3 chr2 175176258 175184607 - G6PC3 chr17 44070735 44076344 + ZSCAN30 chr18 35251058 35290245 - MDN1 chr6 89642498 89819794 - GSTP1 chr11 67583742 67586656 + MARCKSL1 chr1 32333839 32336233 - PSMD2 chr3 184299198 184309050 + XPO6 chr16 28097979 28211920 - EIF3A chr10 119033670 119080823 - AL136454.1 chr1 192716132 192716653 + PIK3CA chr3 179148114 179240093 + COL11A2 chr6 33162681 33192499 - ZNF24 chr18 35332227 35345482 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand BX284668.2 chr1 16870945 16883659 + LINC01783 chr1 16533886 16536172 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.