exRNAdisease

Entry Detail

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General Information

Database ID: exR0359367 RNA Name: ADAM19 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 157395534 End Site(bp): 157575775 External Links: ENSG00000135074

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGO4 chr1 35808016 35857890 + AICDA chr12 8602170 8612867 - BZW1 chr2 200810594 200827338 + CALM3 chr19 46601074 46610782 + DDX17 chr22 38483438 38507660 - EIF3J chr15 44537125 44563029 + FKBP1A chr20 1368978 1393172 - FOCAD chr9 20658309 20995955 + GTF3C2 chr2 27325849 27357034 - IGFBP2 chr2 216632828 216664436 + LRP5L chr22 25351418 25405377 - MGST3 chr1 165631213 165661796 + MYH9 chr22 36281277 36388067 - NDST1 chr5 150485818 150558211 + PRDX5 chr11 64318121 64321811 + PSMD8 chr19 38374536 38383824 + PTPN6 chr12 6946468 6961316 + RAB1B chr11 66268590 66277492 + RNF5 chr6 32178405 32180793 + RPL13 chr16 89560657 89566828 + SLC38A1 chr12 46183063 46270017 - SMARCA4 chr19 10960825 11079426 + STMN1 chr1 25884181 25906991 - TATDN2 chr3 10248023 10281218 + TMEM60 chr7 77793728 77798434 - VPS18 chr15 40894450 40903975 + ZNF354B chr5 178859953 178888122 + ZNHIT2 chr11 65116403 65117701 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-423-5p chr17 30117095 30117117 + circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.