exRNAdisease

Entry Detail

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General Information

Database ID: exR0359371 RNA Name: ADAM23 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 206443532 End Site(bp): 206621127 External Links: ENSG00000114948

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ASCC2 chr22 29788609 29838304 - C10orf82 chr10 116663696 116670264 - C20orf27 chr20 3753508 3768387 - CABP1 chr12 120640552 120667324 + CBL chr11 119206298 119313926 + DDOST chr1 20651767 20661544 - DHRS7B chr17 21123364 21193265 + EIF5A chr17 7306999 7312463 + GMDS chr6 1623806 2245605 - GRINA chr8 143990056 143993415 + HERC2 chr15 28111040 28322172 - HMGB2 chr4 173331376 173334432 - HSP90AB1 chr6 44246166 44253888 + HSP90B1 chr12 103930107 103953645 + IVNS1ABP chr1 185296388 185317273 - MDC1 chr6 30699807 30717447 - NPM1 chr5 171387116 171411137 + PIP4P1 chr14 20457719 20461612 - RPL13 chr16 89560657 89566828 + RPL23 chr17 38847860 38853764 - RRAGA chr9 19049427 19051025 + SLC39A6 chr18 36108531 36129385 - TEKT3 chr17 15303811 15341632 - TMUB2 chr17 44186970 44191929 + USP1 chr1 62436297 62451804 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.