exRNAdisease

Entry Detail

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General Information

Database ID: exR0359378 RNA Name: ADAMTS1 RNA Type: mRNA Chromosome: chr21 Starnd: - Coordinate: Start Site(bp): 26835755 End Site(bp): 26845409 External Links: ENSG00000154734

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RBM39 chr20 35701347 35742312 - KATNBL1 chr15 34140674 34210096 - SCRN1 chr7 29920104 29990289 - NPIPA8 chr16 18317942 18336736 - HECTD4 chr12 112160188 112382439 - MRPL38 chr17 75898643 75905413 - IDH2 chr15 90083045 90102504 - SEC31A chr4 82818509 82901166 - HNRNPCL2 chr1 13115488 13116854 - TMEM259 chr19 1009648 1021179 - RECQL5 chr17 75626845 75667189 - TAX1BP3 chr17 3662895 3668679 - MARK4 chr19 45079288 45305284 + GPI chr19 34359480 34402413 + HCFC1 chrX 153947557 153971818 - FAM13B chr5 137937960 138051961 - TAOK2 chr16 29973868 29992261 + TM9SF3 chr10 96518110 96587452 - MINDY4 chr7 30771417 30892387 + KIF13A chr6 17759183 17987635 - SOX9 chr17 72121020 72126416 + ATIC chr2 215311956 215349773 + RRM1 chr11 4094707 4138932 + TMEM179B chr11 62787402 62790400 + UBE2W chr8 73780097 73878910 - GMPPB chr3 49716844 49723951 - EMC9 chr14 24138959 24141591 - AC087289.3 chr17 75898645 75930129 - SON chr21 33543038 33577481 + PIP4K2A chr10 22534854 22714578 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC040160.2 chr16 67261108 67263784 + GATA2-AS1 chr3 128489212 128502970 + RMRP chr9 35657751 35658018 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.