exRNAdisease

Entry Detail

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General Information

Database ID: exR0359405 RNA Name: ADCK2 RNA Type: mRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 140672945 End Site(bp): 140696261 External Links: ENSG00000133597

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TXNIP chr1 145992435 145996579 - RPL13A chr19 49487554 49492308 + RPS25 chr11 119015712 119018691 - RBM47 chr4 40423267 40630875 - INPPL1 chr11 72223701 72239147 + CCAR2 chr8 22604632 22621514 + PLCXD1 chrX 276322 303356 + ITGB2 chr21 44885953 44931989 - NDUFV1 chr11 67605653 67612554 + POGK chr1 166839447 166856344 + MTRNR2L12 chr3 96617188 96618236 - POC1A chr3 52075226 52154690 - HBS1L chr6 134960378 135103056 - RPL27A chr11 8682788 8714759 + RPL35 chr9 124857880 124861981 - NYNRIN chr14 24399003 24419283 + PTMA chr2 231706895 231713541 + TUBA1C chr12 49188736 49274603 + SOX11 chr2 5692384 5701385 + LARP4B chr10 806914 931705 - NDUFB2 chr7 140690777 140722790 + HNRNPA2B1 chr7 26173057 26201529 - RBMX chrX 136848004 136880764 - RPS3 chr11 75399515 75422280 + SPEN chr1 15836095 15940456 + COX10 chr17 14069490 14231736 + ABCA2 chr9 137007234 137028922 - CSE1L chr20 49046246 49096960 + DDHD2 chr8 38225218 38275558 + LSM12 chr17 44034328 44067619 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.