exRNAdisease

Entry Detail

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General Information

Database ID: exR0359406 RNA Name: ADCY1 RNA Type: mRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 45574140 End Site(bp): 45723116 External Links: ENSG00000164742

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HLA-A chr6 29941260 29945884 + RBMXL1 chr1 88979456 88992960 - CTTN chr11 70398404 70436584 + SCYL1 chr11 65525077 65538704 + FP565260.1 chr21 5130871 5154658 - ICE1 chr5 5420664 5490220 + GNAS chr20 58839718 58911192 + NFATC2IP chr16 28950807 28967097 + SV2A chr1 149903318 149917844 - GLRX3 chr10 130136391 130184521 + LAMA5 chr20 62307955 62367312 - MFSD1 chr3 158732198 158829719 + TMEM185A chrX 149596556 149631912 - UBXN4 chr2 135741734 135785056 + C6orf62 chr6 24704861 24719998 - SZRD1 chr1 16352575 16398145 + PWP2 chr21 44107373 44131181 + MBP chr18 76978827 77133683 - ATP5MC2 chr12 53632726 53677408 - KLF2 chr19 16324817 16327874 + GAPDH chr12 6534512 6538374 + KAT2A chr17 42113111 42121367 - HUWE1 chrX 53532096 53686728 - RAB5A chr3 19947097 19985175 + PHB2 chr12 6965327 6970753 - MARCKS chr6 113857345 113863475 + SUMO3 chr21 44805617 44818779 - NCOA6 chr20 34689097 34825651 - FBRSL1 chr12 132489551 132585188 + LAMB1 chr7 107923799 108003187 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC00665 chr19 36313067 36331770 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.