exRNAdisease

Entry Detail

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General Information

Database ID: exR0359408 RNA Name: ADCY2 RNA Type: mRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 7396138 End Site(bp): 7830081 External Links: ENSG00000078295

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RTN4 chr2 54972187 55112621 - RBBP5 chr1 205086142 205122015 - DMAC1 chr9 7796500 7888380 - HIPK2 chr7 139561570 139777998 - GDI2 chr10 5765223 5842132 - TUFT1 chr1 151540305 151583583 + ACTR1B chr2 97655939 97664044 - NAP1L1 chr12 76036585 76084958 - KREMEN2 chr16 2964216 2968383 + RASSF8 chr12 25959029 26079892 + CTSV chr9 97029677 97039643 - SH3BP4 chr2 234952017 235055714 + ZSCAN10 chr16 3088890 3099295 - PHB2 chr12 6965327 6970753 - ADCY5 chr3 123282296 123449758 - SDCBP chr8 58552924 58582859 + CRABP1 chr15 78340353 78348225 + HSP90AB1 chr6 44246166 44253888 + LIN28A chr1 26410817 26429728 + DSG2 chr18 31498177 31549008 + AURKAIP1 chr1 1373730 1375495 - OGG1 chr3 9749944 9788219 + APEH chr3 49674014 49683971 + GNAS chr20 58839718 58911192 + PSMD10 chrX 108084207 108091549 - SF3B1 chr2 197388515 197435091 - PANK1 chr10 89579497 89645572 - MYL6 chr12 56158161 56163496 + ANAPC15 chr11 72106378 72112780 - YWHAE chr17 1344275 1400222 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.